Human PBMC atlas - B naive cells

Summary

Metadata

Dataset Type

Integrated. The file includes an integrated collection of datasets.

Total Cells

463,552

organism

Homo sapiens

tissue

blood

assay

10x 5' v2 (139,390 cells)10x 5' v1 (133,417 cells)10x 3' v2 (130,244 cells)10x 3' v3 (60,501 cells)

disease

normal (203,018 cells)COVID-19 (196,240 cells)systemic lupus erythematosus (46,988 cells)respiratory system disorder (5,006 cells)post-COVID-19 disorder (4,085 cells)bacterial pneumonia (2,689 cells)infectious disease with sepsis (2,495 cells)infectious disease (2,327 cells)influenza (451 cells)viral pneumonia (253 cells)

Cell Labels

Level_4

Description

Clustering was Leiden based before manual annotation and consensus agreement by multiple authors.

Annotation Method

manual

Cell Labels (8)

Cells (463,552)

B early activated BCR

102,634

B mature naive C1orf56

89,927

B transitional

70,722

B mature naive

67,181

B early activated IL4Rhigh

51,640

B mature naive CHI3L2

42,195

B early activated ISG

34,114

B early activated APC

5,139

Level_1

Description

Similar clusters with shared features from level 2 were manually merged to one level higher in the hierarchy to determine clustering.

Annotation Method

manual

Cell Labels (1)

Cells (463,552)

B_plasma

463,552

Level_2

Description

Similar clusters with shared features from level 3 were manually merged to one level higher in the hierarchy to determine clustering.

Annotation Method

manual

Cell Labels (1)

Cells (463,552)

B naive

463,552

Level_3

Description

Similar clusters with shared features from level 4 were manually merged to one level higher in the hierarchy to determine clustering.

Annotation Method

manual

Cell Labels (1)

Cells (463,552)

B naive/transitional

463,552