Human PBMC atlas - plasma cells

Summary

Metadata

Dataset Type

Integrated. The file includes an integrated collection of datasets.

Total Cells

37,117

organism

Homo sapiens

tissue

blood

assay

10x 5' v1 (25,020 cells)10x 5' v2 (4,321 cells)10x 3' v2 (4,209 cells)10x 3' v3 (3,567 cells)

disease

COVID-19 (25,126 cells)normal (8,600 cells)infectious disease with sepsis (1,491 cells)systemic lupus erythematosus (688 cells)influenza (413 cells)bacterial pneumonia (386 cells)respiratory system disorder (144 cells)post-COVID-19 disorder (132 cells)viral pneumonia (94 cells)infectious disease (43 cells)

Cell Labels

Level_4

Description

Clustering was Leiden based before manual annotation and consensus agreement by multiple authors.

Annotation Method

manual

Cell Labels (6)

Cells (37,117)

Plasma IgA switched

13,258

Plasma IgG switched

11,129

Plasmablasts proliferating

9,919

Plasma unswitched

1,396

Plasmablasts

1,098

Plasma IgD

317

Level_1

Description

Similar clusters with shared features from level 2 were manually merged to one level higher in the hierarchy to determine clustering.

Annotation Method

manual

Cell Labels (1)

Cells (37,117)

B_plasma

37,117

Level_2

Description

Similar clusters with shared features from level 3 were manually merged to one level higher in the hierarchy to determine clustering.

Annotation Method

manual

Cell Labels (1)

Cells (37,117)

Plasma

37,117

Level_3

Description

Similar clusters with shared features from level 4 were manually merged to one level higher in the hierarchy to determine clustering.

Annotation Method

manual

Cell Labels (2)

Cells (37,117)

Plasma

26,100

Plasmablast

11,017