We present the Human Liver Cell Atlas (HLiCA), integrating non-disease liver data from eight datasets across six research centers, covering 525,000+ cells from 110 donors. Developed in collaboration with the Human Cell Atlas Liver Bionetwork, the atlas incorporates expert-reviewed cell annotations, extensive feedback, and focused jamborees for refining myeloid and hepatocyte classifications.
Epithelial cells lining the bile ducts, involved in bile production and modification. These are version 1 cell type labels and may be subject to change.
Structural and supportive cells including fibroblasts and stellate cells, contributing to liver architecture. These are version 1 cell type labels and may be subject to change.
Innate immune cells including macrophages and dendritic cells, key in tissue homeostasis and immune surveillance. These are version 1 cell type labels and may be subject to change.
Adaptive immune cells such as T cells, B cells, and NK cells, involved in immune regulation and response. These are version 1 cell type labels and may be subject to change.
Cells lining the liver vasculature, including liver sinusoidal endothelial cells, regulating filtration and cell trafficking. These are version 1 cell type labels and may be subject to change.
The main parenchymal liver cells responsible for metabolism, detoxification, and protein synthesis. These are version 1 cell type labels and may be subject to change.
