Human lymph node slices cultured with and without ex vivo stimulation by liposomal TLR4 and QS-21 adjuvant

Mast_cells

Ontology Term

mast cellCL:0000097

Synonyms

Terms that have the same, or nearly the same, meaning as the selected cell type.

unknown

Category

Class of which the cell type is a subclass.

myeloid leukocyteCL:0000766

Ontology Assessment

Disagreements with any aspect of the Cell Ontology.

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Marker Gene Evidence

Gene markers used by researcher to assign this cell annotation.

TPSB2, TPSAB1, SIGLEC6

Canonical Marker Genes

TPSB2, TPSAB1, SIGLEC6

Rationale

This cell type was annotated due to expression of tryptase genes (canonical markers)

Inherited from final annotation

Set of Labels Description

Cell annotations were based on the finest possible label to describe the 18 clusters found across both culture conditions (control and stimulated) following integration and clustering. Gene expression across clusters correlated with matched cell annotations in the uncultured, whole lymph node dataset (LN partial T and B cell depletion) in addition to some culture-specific cell clusters

Annotation Method

manual