Single-nucleus transcriptomic profiling of human skeletal muscle from healthy adults

Type I Myonuclei

Ontology Term

slow muscle cellCL:0000189

Synonyms

Terms that have the same, or nearly the same, meaning as the selected cell type.

unknown

Category

Class of which the cell type is a subclass.

extrafusal muscle fiberCL:0008046

Ontology Assessment

Disagreements with any aspect of the Cell Ontology.

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Marker Gene Evidence

Gene markers used by researcher to assign this cell annotation.

MYH7, TNNI1, TNNT1, NEB, MYBPC1, ATP2A2

Canonical Marker Genes

ATP2A2, FKBP5, SOX6, TPM3, MLIP, MYBPC1, NEB, SVIL, TRDN, TTN

Rationale

Type I (slow-twitch) myonuclei were assigned based on enrichment of NEB, MYBPC1, TRDN, ATP2A2, GBE1, and MLIP, with NEB and MYBPC1 preferentially expressed compared to the type II cluster.

Inherited from author_cell_type

Set of Labels Description

Cell annotations were generated with scType using marker genes curated from related publications, and then manually reviewed and adjusted based on the top highly variable genes in each Leiden cluster.

Annotation Method

both

Algorithm Name

scType

Algorithm Version

v1

Algorithm URL

https://github.com/IanevskiAleksandr/sc-type