Single-nucleus transcriptomic profiling of human skeletal muscle from healthy adults

Macrophage

Ontology Term

macrophageCL:0000235

Synonyms

Terms that have the same, or nearly the same, meaning as the selected cell type.

unknown

Category

Class of which the cell type is a subclass.

mononuclear phagocyteCL:0000113

Ontology Assessment

Disagreements with any aspect of the Cell Ontology.

—

Marker Gene Evidence

Gene markers used by researcher to assign this cell annotation.

CD163, MERTK, F13A1, CD68, C1QA, C1QB, C1QC, ZEB2

Canonical Marker Genes

CD163, MRC1, MS4A7, MSR1

Rationale

This population shows a classic tissue-resident macrophage signature, including CD163, MERTK, F13A1, ZEB2, RBPJ, and ELMO1, with CD163 and MERTK strongly enriched compared to other clusters.

Inherited from author_cell_type

Set of Labels Description

Cell annotations were generated with scType using marker genes curated from related publications, and then manually reviewed and adjusted based on the top highly variable genes in each Leiden cluster.

Annotation Method

both

Algorithm Name

scType

Algorithm Version

v1

Algorithm URL

https://github.com/IanevskiAleksandr/sc-type