Single-nucleus transcriptomic profiling of human skeletal muscle from healthy adults

Type II Myonuclei

Ontology Term

fast muscle cellCL:0000190

Synonyms

Terms that have the same, or nearly the same, meaning as the selected cell type.

unknown

Category

Class of which the cell type is a subclass.

extrafusal muscle fiberCL:0008046

Ontology Assessment

Disagreements with any aspect of the Cell Ontology.

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Marker Gene Evidence

Gene markers used by researcher to assign this cell annotation.

MYH1, MYH2, MYH4, TNNC2, TNNI2, RBFOX1, SESN1

Canonical Marker Genes

KLHL29, MYLK4, SESN1, TNNI2, TNNT3, MLIP, MYBPC1, NEB, SVIL, TRDN, TTN

Rationale

Type II (fast-twitch) myonuclei show a fast-fiber program, including TTN, RBFOX1, SESN1, CMYA5, GGT7, KLHL29, and WDPCP, with TTN and RBFOX1 strongly biased toward this cluster.

Inherited from author_cell_type

Set of Labels Description

Cell annotations were generated with scType using marker genes curated from related publications, and then manually reviewed and adjusted based on the top highly variable genes in each Leiden cluster.

Annotation Method

both

Algorithm Name

scType

Algorithm Version

v1

Algorithm URL

https://github.com/IanevskiAleksandr/sc-type