Single-nucleus transcriptomic profiling of human skeletal muscle from healthy adults

Fibroblast

Ontology Term

fibroblastCL:0000057

Synonyms

Terms that have the same, or nearly the same, meaning as the selected cell type.

unknown

Category

Class of which the cell type is a subclass.

stromal cellCL:0000499

Ontology Assessment

Disagreements with any aspect of the Cell Ontology.

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Marker Gene Evidence

Gene markers used by researcher to assign this cell annotation.

DCN, COL6A3, COL1A1, COL3A1, LAMA2, LAMC1, NID1, APOD

Canonical Marker Genes

PDGFRA, ABCA8, CFD, COL6A3, DCN, FBN1, GALNT15, GPX3, LAMC1, NEGR1, NOVA1, TGFBR2, TGFBR3

Rationale

Fibroblasts were identified by a strong ECM/stromal program, with high DCN, COL6A3, LAMA2, LAMC1, NID1, and APOD, and clear differential upregulation of matrix components such as DCN and COL6A3.

Inherited from author_cell_type

Set of Labels Description

Cell annotations were generated with scType using marker genes curated from related publications, and then manually reviewed and adjusted based on the top highly variable genes in each Leiden cluster.

Annotation Method

both

Algorithm Name

scType

Algorithm Version

v1

Algorithm URL

https://github.com/IanevskiAleksandr/sc-type