Single-nucleus transcriptomic profiling of human skeletal muscle from healthy adults

T Cell

Ontology Term

T cellCL:0000084

Synonyms

Terms that have the same, or nearly the same, meaning as the selected cell type.

unknown

Category

Class of which the cell type is a subclass.

lymphocyteCL:0000542

Ontology Assessment

Disagreements with any aspect of the Cell Ontology.

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Marker Gene Evidence

Gene markers used by researcher to assign this cell annotation.

PTPRC, CD3D, CD3E, FYN, ETS1, SKAP1, ARHGAP15

Canonical Marker Genes

CD247, CD96, FYN, HLA-B, IL7R, SKAP1, STAT4, THEMIS

Rationale

This cluster represents T cells, characterized by expression of PTPRC (CD45), FYN, ETS1, ARHGAP15, SKAP1, PIP4K2A, and PRKCH, with PTPRC and SKAP1 clearly separating this population from other immune subsets.

Inherited from author_cell_type

Set of Labels Description

Cell annotations were generated with scType using marker genes curated from related publications, and then manually reviewed and adjusted based on the top highly variable genes in each Leiden cluster.

Annotation Method

both

Algorithm Name

scType

Algorithm Version

v1

Algorithm URL

https://github.com/IanevskiAleksandr/sc-type

• v1 Tissue-wide single-cell multiomic analysis of human gene regulation and cell diversity
• Single-nucleus transcriptomic profiling of human skeletal muscle from healthy adults