Single-nucleus transcriptomic profiling of human skeletal muscle from healthy adults

T Cell

Ontology Term: T cellCL:0000084
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: unknown
Category Class of which the cell type is a subclass.: lymphocyteCL:0000542
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: PTPRC, CD3D, CD3E, FYN, ETS1, SKAP1, ARHGAP15
Canonical Marker Genes: CD247, CD96, FYN, HLA-B, IL7R, SKAP1, STAT4, THEMIS
Negative Marker Genes Genes expected to be absent, or expressed at a notably low level, in these cells, and whose absence supports the assignment of this cell annotation.: —
Rationale: This cluster represents T cells, characterized by expression of PTPRC (CD45), FYN, ETS1, ARHGAP15, SKAP1, PIP4K2A, and PRKCH, with PTPRC and SKAP1 clearly separating this population from other immune subsets.

Set of Labels Description: Cell annotations were generated with scType using marker genes curated from related publications, and then manually reviewed and adjusted based on the top highly variable genes in each Leiden cluster.
Annotation Method: both
Algorithm Name: scType
Algorithm Version: v1
Algorithm URL: https://github.com/IanevskiAleksandr/sc-type