Single-nucleus transcriptomic profiling of human skeletal muscle from healthy adults

Mast Cell

Ontology Term: mast cellCL:0000097
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: unknown
Category Class of which the cell type is a subclass.: myeloid leukocyteCL:0000766
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: KIT, FCER1A, FCER1G, CPA3, TPSAB1/TPSB2, SLC24A3, IL18R1
Canonical Marker Genes: CD69, CPA3, KIT, TPSAB1, TPSB2
Negative Marker Genes Genes expected to be absent, or expressed at a notably low level, in these cells, and whose absence supports the assignment of this cell annotation.: —
Rationale: Cells in this cluster exhibit a mast cell phenotype, marked by KIT, SLC24A3, IL18R1, SYTL3, and CHN2, with particularly high and selective expression of KIT and SLC24A3.

Set of Labels Description: Cell annotations were generated with scType using marker genes curated from related publications, and then manually reviewed and adjusted based on the top highly variable genes in each Leiden cluster.
Annotation Method: both
Algorithm Name: scType
Algorithm Version: v1
Algorithm URL: https://github.com/IanevskiAleksandr/sc-type