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Human PBMC atlas - B naive cells | CAP

Single cell atlas of the human peripheral immune system
Human PBMC atlas - B naive cells

Human PBMC atlas - B naive cells

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Level_4 / B early activated BCR
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Richard H. Scheuermann sent refinements 2026-06-18T17:50:31.766Z

Canonical Marker Genes

MS4A1CD79B TCL1A

MS4A1CD79BTCL1ALTBBANK1

LTB and BANK1 from NS-Forest are expressed in all of these B cell subsets but not in the plasma cell and plasmablast subsets

Level_4 / B mature naive C1orf56
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Richard H. Scheuermann sent refinements 2026-06-18T17:50:53.991Z

Canonical Marker Genes

MS4A1CD79B TCL1A

MS4A1CD79BTCL1ALTBBANK1

LTB and BANK1 from NS-Forest are expressed in all of these B cell subsets but not in the plasma cell and plasmablast subsets

Level_4 / B transitional
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Richard H. Scheuermann sent refinements 2026-06-18T17:51:33.208Z

Canonical Marker Genes

MS4A1CD79B TCL1A

MS4A1CD79BTCL1ALTBBANK1

LTB and BANK1 from NS-Forest are expressed in all of these B cell subsets but not in the plasma cell and plasmablast subsets

Level_4 / B mature naive
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Giorgio Cattoretti sent a disagreement 2026-06-18T15:25:13.405Z

VPreB has been debated in the past (https://doi.org/10.4049/jimmunol.161.3.1132) and found NOT to be expressed in mature peripheral B cells, possibly only in a subset of GC. This comment is: shall we keep biomarkers (RNAs) whose translation does not correspond to proteins? Should a note be made? This is a minefield, because there will be proteins (CD5 in B cells) for which RNA will not be detected.