Human PBMC atlas - B naive cells

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Cell Metadata

B early activated IL4Rhigh

Full Name: B early activated IL4Rhigh
Closest Ontology Term: naive B cellCL:0000788
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: unknown
Category Class of which the cell type is a subclass.: B cellCL:0000236
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: Cluster expressing canonical early activated B cell markers and IL4R
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: CD69, IL4R
Canonical Marker Genes: MS4A1, CD79B, TCL1A
Rationale: Cluster expressing canonical early activated B cell markers and IL4R
Rationale DOI: https://doi.org/10.1016/j.clim.2022.109130

Set of Labels Description: Cell annotations were generated through iterative hierarchical clustering. Broad lineages were first identified and then recursively subdivided into finer sublineages and sub-sublineages (e.g., T → CD4 T → Effector CD4 T). Clusters were iteratively re-clustered at multiple resolutions, split or merged based on biological evidence, and refined through repeated quality-control steps. Final annotations were determined by consensus of an international group using canonical marker genes, one-vs-all and all-vs-all differential expression analyses, and cluster relationships within the hierarchical framework. Low-quality cells, doublets, and contaminating populations were identified and removed throughout the annotation process; following each round of removal, datasets were reprocessed and re-clustered to improve cluster resolution and biological consistency before subsequent annotation refinement.
Annotation Method: manual

Full Name: B early activated IL4Rhigh
Closest Ontology Term: naive B cellCL:0000788
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: unknown
Category Class of which the cell type is a subclass.: B cellCL:0000236
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: Cluster expressing canonical early activated B cell markers and IL4R
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: CD69, IL4R
Canonical Marker Genes: MS4A1, CD79B, TCL1A
Rationale: Cluster expressing canonical early activated B cell markers and IL4R
Rationale DOI: https://doi.org/10.1016/j.clim.2022.109130

Set of Labels Description: Cell annotations were generated through iterative hierarchical clustering. Broad lineages were first identified and then recursively subdivided into finer sublineages and sub-sublineages (e.g., T → CD4 T → Effector CD4 T). Clusters were iteratively re-clustered at multiple resolutions, split or merged based on biological evidence, and refined through repeated quality-control steps. Final annotations were determined by consensus of an international group using canonical marker genes, one-vs-all and all-vs-all differential expression analyses, and cluster relationships within the hierarchical framework. Low-quality cells, doublets, and contaminating populations were identified and removed throughout the annotation process; following each round of removal, datasets were reprocessed and re-clustered to improve cluster resolution and biological consistency before subsequent annotation refinement.
Annotation Method: manual