Human PBMC atlas - T/NK proliferating cells

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Summary

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Cell Metadata

Summary

Our T/NK proliferating cells dataset includes 102,775 cells, using canonical markers to distinguish 18 unique subsets.

Metadata

Dataset Type: Integrated. The file includes an integrated collection of datasets.
Total Cells: 102,483
organism: Homo sapiens
tissue: blood
assay: 10x 5' v2 (42,212 cells)10x 5' v1 (39,548 cells)10x 3' v2 (13,250 cells)10x 3' v3 (7,473 cells)
disease: COVID-19 (71,567 cells)normal (20,527 cells)systemic lupus erythematosus (4,973 cells)infectious disease with sepsis (2,367 cells)respiratory system disorder (937 cells)post-COVID-19 disorder (750 cells)influenza (604 cells)bacterial pneumonia (550 cells)infectious disease (150 cells)viral pneumonia (58 cells)

Cell Labels

Level_4

Description

Clustering was Leiden based before manual annotation and consensus agreement by multiple authors.

Annotation Method

manual

Prolif T CD4 Naive/CM

18,757

Prolif NK CD16 PTGDS

9,756

Prolif T CD8 EM - Proli 2

9,631

Prolif NK CD16 adaptive activ NR4A2

9,208

Prolif T CD8 EM TNFAIP3

8,310

Prolif NK CD16 activ FOS_JUN

7,691

Prolif T CD8 CTL

6,522

Prolif T CD8 EM - Proli 3

6,416

Prolif T CD8 CTL mito

5,670

Prolif T CD8 EM - Proli 1

5,545

Prolif NK activ FOS_JUN

5,435

Prolif T CD4 naive quiesc

2,265

Level_1

Description

Similar clusters with shared features from level 2 were manually merged to one level higher in the hierarchy to determine clustering.

Annotation Method

manual

TCD8_innate

78,374

TCD4

24,109

Level_2

Description

Similar clusters with shared features from level 3 were manually merged to one level higher in the hierarchy to determine clustering.

Annotation Method

manual

T CD8 Cycling

44,399

33,975

T CD4 Cycling

24,109

Level_3

Description

Similar clusters with shared features from level 4 were manually merged to one level higher in the hierarchy to determine clustering.

Annotation Method

manual

T CD8 Proliferating

44,399

NK proliferating

33,975

T CD4 Proliferating

24,109

Human PBMC atlas - T/NK proliferating cells

Main

Cell Metadata

Summary

Our T/NK proliferating cells dataset includes 102,775 cells, using canonical markers to distinguish 18 unique subsets.

Metadata

Dataset Type: Integrated. The file includes an integrated collection of datasets.
Total Cells: 102,483
organism: Homo sapiens
tissue: blood
assay: 10x 5' v2 (42,212 cells)10x 5' v1 (39,548 cells)10x 3' v2 (13,250 cells)10x 3' v3 (7,473 cells)
disease: COVID-19 (71,567 cells)normal (20,527 cells)systemic lupus erythematosus (4,973 cells)infectious disease with sepsis (2,367 cells)respiratory system disorder (937 cells)post-COVID-19 disorder (750 cells)influenza (604 cells)bacterial pneumonia (550 cells)infectious disease (150 cells)viral pneumonia (58 cells)